A systematic study of biochemical profile during the induction and development of an animal model for Metabolic Syndrome

Metabolic syndrome is a multiplex risk factor arising from abdominal obesity, insulin resistance and dyslipidemia. It increases the risk for cardiovascular complications, fatty liver disease and cognitive dysfunction. The prevalence is rampantly increasing among all age groups worldwide due to nutrition excess, physical inactivity and increased stress. Despite its epidemiological nature, treatment is limited to lifestyle changes and lifelong medical intervention. This may be due to incomplete knowledge of the etiology of the syndrome. The present study is aimed at developing an animal model using male C57BL/6J mice and studying the biochemical profile during the onset and progression of the syndrome. Test group was fed with High Fat Simple Carbohydrate (HFSC) diet and the Control group was fed with standard diet for a period of 5 months. Body weight and biochemical profile was analyzed on a monthly basis. Oral Glucose tolerance test (OGTT) was performed following a glucose load of 1g/kg body weight at 143 rd day. The syndrome was successfully induced in male C57BL/6J mice within a period of 5 months with perturbed lipid profile and insulin resistance.